DNA損傷有多種檢測(cè)方法，其中Stressmarq的DNA損傷檢測(cè)試劑盒（SKT-120）主要是通過(guò)競(jìng)爭(zhēng)法ELISA檢測(cè)2 8-羥基脫氧鳥(niǎo)苷含量確定DNA損傷的情況。該DNA損傷檢測(cè)試劑盒可以檢測(cè)的樣本類型包括：細(xì)胞裂解液，血漿，尿液。該試劑盒已被85篇文獻(xiàn)引用，產(chǎn)品質(zhì)量穩(wěn)定且精準(zhǔn)。

DNA損傷檢測(cè)試劑盒（SKT-120）信息：

Stressmarq DNA損傷檢測(cè)試劑盒（SKT-120）特點(diǎn)：

1. 檢測(cè)時(shí)間更短  – 新試劑盒的檢測(cè)時(shí)間由原來(lái)的18小時(shí)縮短到僅僅1個(gè)小時(shí)。

2. 穩(wěn)定性更強(qiáng) – 舊款試劑盒的乙酰膽-堿酯酶和 Ellmans’ 試劑盒被替換成 HRP 以及 TMB，增強(qiáng)了穩(wěn)定性，無(wú)需儲(chǔ)存在 -20°C。

3. 簡(jiǎn)化的實(shí)驗(yàn)步驟  – 直接標(biāo)記的一抗以及其他組件的改進(jìn)減少了所需試劑，從而簡(jiǎn)化了實(shí)驗(yàn)步驟。

4. 更廣的檢測(cè)范圍  – 新試劑盒檢測(cè)范圍增加到 0.94 - 60 ng/ml ，這可以減少稀釋步驟并且該范圍可能更適宜生物樣品的讀數(shù) 。

2021年使用Stressmarq DNA損傷檢測(cè)試劑盒（SKT-120）發(fā)表的文獻(xiàn)

● High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages

Jin, Y. et al (2021) J Hazard Mater. 425:128041

PubMed ID: 34906874?Reactivity Human Applications: Bronchial epithelial cell line 16HBE

● Effect of Low-Dose Gamma Lipoic Acid on High- Radiation-Dose Induced Radiation and Rat Brain Injuries.

Abdel-Aziz, N., Elkady, A., Elgazzar, E. (2021) Dose Response 2021:1–13

PubMed ID: 34759786?Reactivity Rat Applications: Brain tissue

● A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway.

Ma, C. et al. (2021) Signal Transduct Target Ther (2021) 6:353

PubMed ID: 34593766?Reactivity P. aeruginosa

● Systemic Profiles of microRNAs, Redox Balance, and Inflammation in Lung Cancer Patients: Influence of COPD.

Qin, L. et al. (2021) Biomedicines 2021, 9(10), 1347

PubMed ID: 34680465?Reactivity Human Applications: Plasma

● 8-Formylophiopogonanone?B?induces ROS-mediated apoptosis in nasopharyngeal carcinoma CNE-1 cells

Zhang, Y. et al. (2021) Toxicol. Res. Online ahead of print.

PubMed ID: N/A

● Experimental evidence that social instability influences rank-specific patterns in oxidative stress in a cichlid fish.

Border, S.E. et al. (2021) J Exp Biol. jeb.237172

PubMed ID: 34495308?Reactivity Fish

● Effects of prenatal stress deficiency in C57BL/6 mice on and/or forebrain ATRX cellular metabolism, DNA damage, ATM promoter methylation and gene expression.

Maillet, H. M. (2021) Dalhousie University Masters Thesis

PubMed ID: N/A Reactivity Mouse Applications: pre frontal cortex, hippocampus and cerebellum

● Evaluating the Effects of Commiphora Molmol (Myrrh) Against Oxidative DNA Damage in Human Lymphocytes.

Daradka, H. et al. (2021) IJPSR 12(6): 3143-3149

PubMed ID: N/A Reactivity Human Applications: Lymphocytes

● Curcumin Modulates Nitrosative Stress, Inflammation, and DNA Damage and Protects against Ochratoxin A-Induced Hepatotoxicity and Nephrotoxicity in Rats.

Longobardi, C. et al. (2021) Antioxidants 10(8), 1239

PubMed ID: 34439487?Reactivity Rat Applications: Urine

● Oxidative Stress in Cerebrospinal Fluid During Treatment in Childhood Acute Lymphoblastic Leukemia.

Dewan, P. et al. (2021) Cureus 13(6): e15997

PubMed ID: 34336488?Reactivity Human Applications: Cerebrospinal Fluid

● Changes in Urinary Biomarkers of Organ Damage, Inflammation, Oxidative Stress, and Bone Turnover Following a 3000-m Time Trial

Tominaga, T. et al. (2021) Antioxidants 2021, 10, 79

PubMed ID: 33435279?Reactivity Human Applications: Urine